TERRITREM : NEUROTOXICITY AND BIOTRANSFORMATION

Industrial Biotransformation*

Biocatalysis or biotransformation encompasses the use of biological systems to catalyze the conversion of one compound to another. The catalyst part of the biological system can thereby consist of whole cells, cellular extracts, or isolated enzyme(s). Up to the second decade of the twentieth century, processes based on biotransformations were classified under various denominations such as ‘‘zym...

Biodegradation, biotransformation, and biocatalysis (b3).

Biodegradation, Biotransformation, and Biocatalysis (B3) R. E. Parales,* N. C. Bruce, A. Schmid, and L. P. Wackett Department of Microbiology and Center for Biocatalysis and Bioprocessing, The University of Iowa, Iowa City, Iowa; Department of Biochemistry, Molecular Biology and Biophysics, Biotechnology Institute, University of Minnesota, St. Paul, Minnesota; Institute of Biotechnology, Univer...

Biotransformation and Rearrangement of Laromustine.

This review highlights the recent research into the biotransformations and rearrangement of the sulfonylhydrazine-alkylating agent laromustine. Incubation of [(14)C]laromustine with rat, dog, monkey, and human liver microsomes produced eight radioactive components (C-1 to C-8). There was little difference in the metabolite profile among the species examined, partly because NADPH was not require...

Managing biotransformation: introduction and overview.

Biotransformation of Xenobiotics and Hormones